Diazepam does not alter the pharmacokinetics of propranolol.
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Competitive in vitro ligand binding studies have also shown diltiazem hydrochloride binding is not altered by therapeutic concentrations of digoxin, hydrochlorothiazide, phenylbutazone, propranolol, salicylic acid, or warfarin.
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Interestingly, nk natural killer cell activity may be decreased during propranolol therapy, although the number of circulating nk cells may remain unchanged.
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